Born in 1981, Ryan Wolfe attended after graduating from high school college in Boston, where he graduated top of his class with a degree in Chemistry and a Master of Science in Genetics. He then attended the police academy and began his activities on patrol of the Miami Dade Police Department. In his youth, Ryan learned from a safecracker, his uncle, how to crack a safe. This skill sometimes comes in handy from his later work.

As part of a crime scene investigation, Horatio Caine gets to know patrolman Wolfe. After Tim Speedle was shot, a spot became vacant in the team, now occupied by with Ryan Wolfe (played by Jonathan Togo) thanks to Caine.

Ryan Wolfe, who has a strong sense of order, is the youngest investigator of the team in the series CSI: Miami. He is well aware that he will not be able to replace Speedle ??. Still, he tries to give his best in his work and says of himself that he only wants to perform his job thoroughly.

Eric Delko believes, however, that Wolfe is trying to prove he is better than Speedle. Since Eric cannot keep his opinion to himself, the relationship between the two men is often more tensioned. However, this changes gradually with the episodes.

When Eric did not even respond to a call for an investigation, Ryan takes over the investigation, during which he is seriously injured with a nail gun next to his right eye. Eric Delko finds the injured and drives him to the hospital. This incident also helps the two become closer friends.

Ryan Wolfe is a very ambitious but often impulsive man, who is often led to trouble by it. He has stopped several policemen from taking out a family from their home during a family affair, and in this context also attacked one of the policemen present. The injunction, which the policeman has obtained against Wolfe, could definitely cause problems in his profession.

Every now and then, Wolfe turns to betting and games. Because of his addiction, he is suspended from duty. Initially he worked as the TV presenter of a mystery show, but he resigns after it becomes clear that the audience should only be instigated. He has also worked for a criminal lawyer for a while, and had worked against his former teammates in his role.

After he had given up that job, he worked at a shooting range, where he later met Natalia Boa Vista, which went about their training here in order to obtain her gun license. Wolfe, however, gets a second chance from Lieutenant Caine and ultimately returns to the team.